The Extraction And Purification Of Paracetamol Essay

The Extraction And Purification Of Paracetamol Essay Analysing the Quantity and Purity of Paracetamol Present in Different Formulations of the Commercial Medicine Aim The aim of this investigation was to determine the percentage by mass of pure paracetamol in formulations of branded paracetamol in 500mg tablets. Two techniques were used so as to determine this: -Extraction and purification of tablets by filtration and recrystallisation. -Hydrolysis of the drug under reflux followed by titration against ammonium cerium sulphate. In addition to this, the purity of the paracetamol was investigated by determination of melting point of the respective brands of paracetamol. Findings Using the extraction and purification procedure it was found that Tesco had the greatest percentage by mass of the active ingredient, paracetamol, at 46.8%. Morrisons tablet percentage by mass was 44.6% while Superdrug had a percentage by mass of 37.8%. Using the reflux and titration procedure it was found that Superdrug had the greatest percentage by mass of the active ingredient, paracetamol at 20.0%. The Tesco percentage by mass was 19.6% while Morissons was 18.5%. The melting point procedure concluded that all three crude samples had similar purity of paracetamol with melting point at 156oC. The melting point of the Morrisons recrystallised paracetamol was 168oC, Superdrug had a melting point of 165oC while Tesco had a melting point of 164oC. This shows that Morrisons had the highest purity of pure paracetamol followed by Superdrug and then Tesco. Underlying ChemistryHistory and Uses Paracetamol (C8H9NO2) (or acetaminophen) is the most common over the counter painkiller in the world. It was discovered in 1852 by Charles Fredric Gerhardt who later went on to discover aspirin. The drug is so popular due to the few side effects it has on the body and does not irritate the stomach like other commonly used drugs such as aspirin. The structure is as shown: Paracetamol is used for relief of headaches, fever, menstrual pain, back pain, toothache and other general pain; however it is ineffective against muscle pain as it possesses no anti-inflammatory properties. Non-opioid analgesics work by inhibiting an enzyme known as cyclooxygenase (COX). COX is a catalyst for the conversion of a fatty acid contained in cell walls—arachidonic acid—to substances known as prostaglandins. (tuftsjournal.tufts.edu.) Prostaglandins have many functions including the induction of pain. By reducing the production of prostaglandins the pain is relieved. Paracetamol does not affect the cause of the pain but rather combats the biochemical pathway which results in the feeling of pain. Prostaglandins also affect the hypothalamus in the brain, the centre which is responsible for the maintenance of our bodies internal environment despite changes to the external environment, i.e. homeostasis. The prostaglandins cause the body to raise its temperature, and hence by taking paracetamol the body temperature is lowered. Paracetamol is therefore classed as antipyretic as it lowers the body temperature. Due to these properties the drug is commonly used to combat flu and cold symptoms. The range of pain combatted by paracetamol alongside the fact that it has very few side effects has resulted in it being the most commonly used painkiller. Paracetamol is also popular because of the rate at which pain subsides from its use due to the rapid uptake in the body. Absorption: Rapidly and almost completely absorbed from the G.I. tract. Peak plasma concentrations are reached in 10-60 minutes.(labmed.yale.edu) Methodology Two techniques were used in the determination of the mass of active ingredient present in the tablets. The first was the extraction and purification of paracetamol from tablets. The second was an acid catalysed hydrolysis under reflux followed by titrations against ammonium cerium sulphate. The use of the melting point allowed the purity of the paracetamol to be determined. The extraction and purification of paracetamol This procedure extracted paracetamol from the tablets by crystallisation. The paracetamol tablets were crushed and dissolved in propanone at a raised temperature; this decreased the time required for the paracetamol to dissolve. The binding agents and fillers in the tablet are insoluble in propanone however the paracetamol is soluble. This results in the paracetamol forming a solution in the propanone while the other components of the tablet are left as insoluble residue. The solution was filtered to remove the residue. The filtrate was left to evaporate forming crystals of paracetamol. These crystals were then dissolved in hot water and then filtered through cotton wool to remove any binding agents left. This filtrate was left in the fridge and shards of paracetamol formed. This relies on the fact that paracetamol has a high solubility in hot water but a low one in cold water. This allows shards of paracetamol to form. The soluble impurities are only present to the level of a few percent and so never reach their limit of solubility and thus stay in solution. (Ellis, 2002) The pure recrystallised paracetamol was then dried and its mass measured. The percentage by mass was then calculated. Reflux and titrations This procedure required the paracetamol to be boiled under reflux for one hour with sulphuric acid. This acid catalysed hydrolysis broke down the paracetamol (an amide) into an amine (4-aminophenol) and a carboxylic acid (ethanoic acid.) The raised temperature was used so as thermally accelerate the reaction. The reaction is shown below: (Overall reaction) This reaction mechanism may be found in the appendix. The use of reflux apparatus ensured that the reaction vessel never boiled dry. This is because any vapour formed from heating in the reaction vessel was turned back into a liquid by condensation. The benefit of using a heating mantle was that it ensured that a constant temperature, heating the round bottomed flask over a greater surface area. This procedure produced 4-aminophenol. This has a hydroxyl group on carbon 1 and an amine group on the carbon 1. Since the nitrogen is attached to only one carbon it is a primary amine. The 4-aminophenol can then be oxidised using ammonium cerium sulphate, involving the loss of hydrogen from the 4-aminophenol using ferroin as an indicator. This produced iminoquinone. Only after all the 4-aminophenol has been oxidised will the cerium (IV) reagent oxidise the ferroin indicator from Fe2+ to Fe3+ (ferriin). (Ellis, 2002) This resulted in the colour change from red to yellow, as the red ferroin is oxidised to ferriin which is blue. This is shown in the diagram below When mixed with the ammonium cerium sulphate this produced a yellow colour which indicated the end point of the titration. A titration was also carried out without the test material being present and the difference between the values with the test species present and absent accounted for the mass of paracetamol present. The difference in volumes of titre required for the colour change is directly proportional to the mass of paracetamol present in the tablet (0.007560g per 1cm3 equivalent titre.) Melting Point By measuring the melting points of the given formulations, the purity of the paracetamol was able to be determined. Melting point apparatus worked by heating the species in a capillary tube which itself was inserted into a heating block. By looking through a lens at the species, the moment at which the species melted could be seen and then at this moment the reading on the thermometer could be viewed. When a substance is heated, there is an increase in entropy as the species is thermally excited. If enough energy is put into the substance, it results in a change of state, in this case solid to liquid. The three brands of paracetamol melting points were measured for the tablet, the crude and the recrystallised samples. Pure paracetamol is a white crystalline solid which melts at 169-171oC. (Ellis 2002). The impurities in the samples lower the melting points. The sample which was closest to the given melting point represents the purest sample of paracetamol. Procedures The Extraction and Purification of Paracetamol Please note this experiment was carried out twice for each brand and an average taken. This was then duplicated so as to improve the reliability. (This is shown in results as the replicate.) Paracetamol was extracted from three brands of paracetamol; Morrisons, Superdrug and Tesco. These procedures represent the procedure used for each brand. Two tablets were weighed using a balance (accurate to 2 D.P.) then crushed using a mortar and pestle. The ground tablets were placed in a beaker. 50cm3 of propanone was measured using a pipette. The propanone was used to rinse the mortar and pestle before adding it to the beaker. The beaker was left on a brisk stir at a low heat until the tablet was dissolved as far as possible. The insoluble material was the binding agents and fillers. Initially 20cm3 of propanone was used however it was found that the tablets did not dissolve fully. A Buchner Funnel was set up as shown (see left.) The insoluble material (binding agents and fillers) collects in the filter paper. The filtrate (propanone and paracetamol) is collected in the filtering flask. A little propanone was run through the filter paper so as to create a seal between the filter paper and the base as shown on the above diagram. This prevented the insoluble material from passing through the holes in the funnel. The content of the beaker was passed through the funnel and a little propanone was used to rinse the beaker. The filtrate was left in an evaporating basin overnight in an oven. This formed crude paracetamol crystals. The mass of the crystals was taken. The crystals were placed in a beaker and 20cm3 of hot water was added. The beaker was heated on a brisk stir until the paracetamol had dissolved. This was passed through a warmed wet piece of cotton wool in a warmed glass funnel. This was to prevent the paracetamol from recrystallising in the cotton during filtration. The filtrate was passed directly into a basin. The basin was placed in the fridge overnight to cool and to allow the crystals to form. These crystals were white. The recrystallised paracetamol in water was passed through a piece of fluted filter paper to collect the crystals. (Initially the paracetamol was filtered out of the water using a sintered glass crucible however this produced a lower yield as crystals were lost when using this technique. See table 22.) The filter paper and crystals were placed in an oven at room temperature overnight to allow the crystals to dry. These crystals were white. The dry mass of the crystals was measured. This procedure was replicated for each brand of paracetamol. Reflux and titrations Please note that this procedure was carried out once for each brand of paracetamol. This was then duplicated so as to improve the reliability. (This is shown in the results as the replicate.) The first stage of this procedure involved the acid hydrolysis of paracetamol: 15cm3 of 2 molar solution of sulphuric acid and 25cm3 of water were measured using a pipette and placed in a 100ml round bottomed flask. To this 0.30g of crushed (using mortar and pestle) paracetamol tablet was added, having measured the paracetamol using a balance (accurate to 2 D.P.) This was swirled and warmed until the tablet was dissolved. This was then boiled under reflux for one hour in a heating mantle as shown below: The paracetamol and sulphuric acid were placed nn the round bottomed flask. The solution turned from colourless to a light golden colour. The solution was cooled and 100cm3 of water was added. 20cm3 of the resulting solution was pipetted into a conical flask with 15cm3 of 2 molar Hydrochloric acid, 40cm3 of water and precisely 8 drops of ferroin indicator. This was then titrated against 0.1 molar solution of ammonium cerium sulphate until colour changed from a pink/peach colour to a cloudy yellow colour. (The colour change was not very obvious during this procedure. Therefore previous titration colours were kept beside the species to try to standardize the colour at which the end point of the titration was determined.) The titrations were repeated until two results were within 0.1cm3 of each other i.e. until two concordant results were obtained. The apparatus is as shown overleaf: The burette was filled with the yellow ammonium cerium sulphate solution and the conical flask contained the paracetamol acid mixture. This procedure was also repeated without the test material present. Melting Point During this procedure, the melting points of the recrystallised, crude and unaltered tablet forms of paracetamol were investigated. The sample of species was crushed into a powder using a mortar and pestle. Capillary tubes (1mm diameter, 10cm long) were sealed at one end using a Bunsen burner. This provided a place to hold the paracetamol when using the melting point apparatus. The capillary tube was placed turned open-side-down and pressed onto the paracetamol formulations. Then the closed end of the capillary tubes was gently tapped on the table to allow the paracetamol to fall to the closed end. This was then placed open-side-up into the metal heating block alongside a thermometer. The temperature was slowly increased using the thermostat on the melting point apparatus while the paracetamol was viewed through the magnifying glass on the apparatus. The point at which the paracetamol melted was then recorded. Results Initial Extraction and purification The crystals of the crude and recrystallised paracetamol were both white. The crude crystals were prismatic shaped while the recrystallised paracetamol formed long shards. Table 1 shows the mass of crude paracetamol from each tablet: Table 1 Brand Mass (g) Sample 1 Sample 2 Average Tesco 0.94 1.00 0.97 Morrisons 1.01 1.00 1.01 Superdrug 0.97 0.92 0.95 Table 2 shows the mass of recrystallised paracetamol from each tablet: Table 2 Brand Mass (g) Sample 1 Sample 2 Average Tesco 0.58 0.49 0.54 Morrisons 0.44 0.49 0.47 Superdrug 0.36 0.48 0.42 Table 3 shows the percentage by mass of crude paracetamol compared to the mass of two tablets (1.10g): Table 3 Brand Percentage of Crude Paracetamol (%) Tesco 88.2 Morrisons 91.8 Superdrug 86.4 (Calculations may be found in the appendix) Table 4 shows the mass of recrystallised paracetamol compared to the respective mass of two tablets (1.10g): Table 4 Brand Percentage of pure Paracetamol (%) Tesco 49.1 Morrisons 42.7 Superdrug 38.2 (Calculations may be found in the appendix) Reflux and titrations Table 5 shows the volume of Ammonium Cerium sulphate required for the colour change from red to yellow to occur without the test species present (paracetamol): Table 5 Titration Initial Titre (cm3) Final Titre (cm3) Volume of ammonium cerium (IV) sulphate needed for the colour change (cm3) Rough 0.0 0.5 0.5 First 0.5 1.0 0.5 Second 1.0 1.5 0.5 Average Titre = (0.5+0.5)/2 = 0.5cm3 Table 6 shows the volume of Ammonium Cerium sulphate required for the colour change from red to yellow to occur using Tesco paracetamol: Table 6 Titration Initial Titre (cm3) Final Titre (cm3) Volume of ammonium cerium (IV) sulphate needed for the colour change (cm3) Rough 0.0 8.6 8.6 First 8.6 15.8 7.2 Second 15.8 23.1 7.3 Average volume = (7.2+7.3)/2 = 7.25cm3 Amended titre = 7.25-0.5 = 6.75cm3 As 1 cm3 of ammonium cerium (IV) sulphate = 0.007560g of Paracetamol 6.75 x 0.007560 = 0.05103g So, if 0.3g of tablet 0.05103g of pure Paracetamol Then, 0.55g of tablet 0.093555g of pure Paracetamol Percentage by mass (0.093555/0.55) x 100 =17.0% Table 7 shows the volume of Ammonium Cerium sulphate required for the colour change from red to yellow to occur using Morrisons paracetamol: Table 7 Titration Initial Titre (cm3) Final Titre (cm3) Volume of ammonium cerium (IV) sulphate needed for the colour change (cm3) Rough 0.0 7.4 7.4 First 7.4 14.4 7.0 Second 14.4 21.5 7.1 Average volume = (7.0+7.1)/2 = 7.05cm3 Amended titre = 7.05-0.5 = 6.55cm3 As 1 cm3 of ammonium cerium (IV) sulphate = 0.007560g of Paracetamol 6.55 x 0.007560 = 0.049518g So, if 0.3g of tablet 0.049518g of pure Paracetamol Then, 0.55g of tablet 0.090783g of pure Paracetamol Percentage by mass (0.090783/0.55) x 100 =16.5% Table 8 shows the volume of Ammonium Cerium sulphate required for the colour change from red to yellow to occur using Superdrug paracetamol: Table 8 Titration Initial Titre (cm3) Final Titre (cm3) Volume of ammonium cerium (IV) sulphate needed for the colour change (cm3) Rough 0.0 9.7 9.7 First 9.7 18.6 8.9 Second 18.8 27.8 9.0 Average volume = (8.9+9.0)/2 = 8.95cm3 Amended titre = 8.95-0.5 = 8.45cm3 As 1 cm3 of ammonium cerium (IV) sulphate = 0.007560g of Paracetamol 8.45 x 0.007560 = 0.063882g So, if 0.3g of tablet 0.063882g of pure Paracetamol Then, 0.55g of tablet 0.117117g of pure Paracetamol Percentage by mass (0.117117/0.55) x 100 =21.3% Table 9 shows the melting points of the paracetamol: Table 9 Brand Melting Point (0C) Tablet Sample Crude Sample Recrystallised Sample Tesco 140 155 163 Morrisons 145 157 167 Superdrug 139 159 164 Replicate Extraction and purification The crystals of the crude and recrystallised paracetamol were both white. The crude crystals were prismatic shaped while the recrystallised paracetamol formed long shards. Table 10 shows the mass of crude paracetamol from each tablet: Table 10 Brand Mass (g) Sample 1 Sample 2 Average Tesco 1.00 0.98 0.99 Morrisons 1.00 1.04 1.02 Superdrug 1.01 0.97 0.99 Table 11 shows the mass of recrystallised paracetamol from each tablet: Table 11 Brand Mass (g) Sample 1 Sample 2 Average Tesco 0.51 0.46 0.49 Morrisons 0.53 0.49 0.51 Superdrug 0.40 0.42 0.41 Table 12 shows the percentage by mass of crude paracetamol compared to the mass of two tablets (1.10g) Table 12 Brand Percentage of crude Paracetamol (%) Tesco 90.0 Morrisons 92.7 Superdrug 90.0 (Calculations may be found in the appendix) Table 13 shows the mass of recrystallised paracetamol compared to the mass of two tablets (1.10g): Table 13 Brand Percentage of pure Paracetamol (%) Tesco 44.5 Morrisons 46.4 Superdrug 37.3 (Calculations may be found in the appendix) Reflux and titrations Table 14 shows the volume of Ammonium Cerium sulphate required for the colour change from red to yellow to occur without the test species present (paracetamol): Table 14 Titration Initial Titre (cm3) Final Titre (cm3) Volume of ammonium cerium (IV) sulphate needed for the colour change (cm3) Rough 0.0 0.5 0.5 First 0.5 1.1 0.6 Second 1.1 1.6 0.5 Average volume = (0.5+0.6)/2 = 0.55 cm3 Table 15 shows the volume of Ammonium Cerium sulphate required for the colour change from red to yellow to occur using Tesco paracetamol: Table 15 Titration Initial Titre (cm3) Final Titre (cm3) Volume of ammonium cerium (IV) sulphate needed for the colour change (cm3) Rough 0.0 10.6 10.6 First 10.6 20.0 9.4 Second 20.0 29.3 9.3 Average volume = (9.3+9.4)/2 = 9.35cm3 Amended titre = 9.35-0.55 = 8.8cm3 As 1 cm3 of ammonium cerium (IV) sulphate = 0.007560g of Paracetamol 8.8 x 0.007560 = 0.066528g So, if 0.3g of tablet 0.066528g of pure Paracetamol Then, 0.55g of tablet 0.121968g of pure Paracetamol Percentage by mass (0.121968/0.55) x 100 =22.2% Table 16 shows the volume of Ammonium Cerium sulphate required for the colour change from red to yellow to occur using Morrisons paracetamol: Table 16 Titration Initial Titre (cm3) Final Titre (cm3) Volume of ammonium cerium (IV) sulphate needed for the colour change (cm3) Rough 21.5 30.5 9.0 First 30.5 39.5 9.0 Second 39.5 47.6 8.1 Third 0.00 8.6 8.6 Fourth 8.6 17.3 8.7 Average volume = (8.7+8.6)/2 = 8.65cm3 Amended titre = 8.65-0.55 = 8.1cm3 As 1 cm3 of ammonium cerium (IV) sulphate = 0.007560g of Paracetamol 8.1 x 0.007560 = 0.061236g So, if 0.3g of tablet 0.061236g of pure Paracetamol Then, 0.55g of tablet 0.112266g of pure Paracetamol Percentage by mass (0.112266/0.55) x 100 =20.4% Table 17 shows the volume of Ammonium Cerium sulphate required for the colour change from red to yellow to occur using Superdrug paracetamol: Table 17 Titration Initial Titre (cm3) Final Titre (cm3) Volume of ammonium cerium (IV) sulphate needed for the colour change (cm3) Rough 0.0 8.3 8.3 First 8.3 16.2 7.9 Second 16.2 24.2 8.0 Average volume = (7.9+8.0)/2 = 7.95cm3 Amended titre = 7.95-0.55 = 7.4cm3 As 1 cm3 of ammonium cerium (IV) sulphate = 0.007560g of Paracetamol 7.4 x 0.007560 = 0.055944g So, if 0.3g of tablet 0.055944g of pure Paracetamol Then, 0.55g of tablet 0.102564g of pure Paracetamol Percentage by mass (0.102564/0.55) x 100 =18.6% Table 18 shows the melting points of the paracetamol: Table 18 Brand Melting Point (0C) Tablet Sample Crude Sample Recrystallised Sample Tesco 143 156 165 Morrisons 144 155 168 Superdrug 141 153 166 Averages of Initial and replicate Table 19 shows percentage by mass of recrystallised paracetamol: Table 19 Percentage by mass% Brand Initial Replicate Average Tesco 49.1 44.5 46.8 Morrrisons 42.7 46.4 44.6 Superdrug 38.2 37.3 37.8 Table 20 shows percentage by mass of pure paracetamol determined from reflux and titrations: Table 20 Percentage by mass % Brand Initial Replicate Average Tesco 17.0 22.2 19.6 Morrisons 16.5 20.4 18.5 Superdrug 21.3 18.6 20.0 Table 21 shows the melting point of paracetamol of crude and recrystallised paracetamol: Table 21 Melting point (oC) Crude Recrystallised Brand Initial Replicate Average Initial Replicate Average Tesco 155 156 156 163 165 164 Morrisons 157 155 156 167 168 168 Superdrug 159 153 156 164 166 165 Table 22 shows the results using a sintered glass crucible rather than filter paper during the filtration of Tesco recrystallised paracetamol: Table 22 Sample 1 Sample 2 Mass of crystals (g) 0.31 0.12 Conclusions The aim of this investigation was to determine the percentage by mass of pure paracetamol in formulations of branded paracetamol in 500mg tablets. Two techniques were employed so as to determine this: -Extraction and purification of tablets by filtration and recrystallisation. -Hydrolysis of the drug under reflux followed by titration against ammonium cerium sulphate. In addition to this, the purity of the paracetamol was investigated by determination of melting point of the respective brands of paracetamol. The results of these procedures are discussed below. Extraction and purification Using this procedure it was found that Tesco had the greatest percentage by mass of the active ingredient, paracetamol, at 46.8%. Morrisons tablet percentage by mass was 44.6% while Superdrug had a percentage by mass of 37.8%. Reflux and Titrations Using this procedure it was found that Superdrug had the greatest percentage by mass of the active ingredient, paracetamol at 20.0%. The Tesco percentage by mass was 19.6% while Morissons was 18.5%. Results were different for each respective brand of paracetamol and different between the two procedures. Melting Point The melting points of the crude paracetamol were all 156oC thus showing that all formulations of crude paracetamol had similar purity, and hence the first crystallization of the paracetamol was carried out very accurately. The melting point of the Morrisons recrystallised paracetamol was 168oC which compared well with the given melting point of 169-171oC. Superdrug had a melting point of 165oC while Tesco had a melting point of 164oc. This shows that Morrisons had the highest purity of pure paracetamol followed by Superdrug and then Tesco. Evaluation Evaluation of procedures Control of variables During the filtration and recrystallising process two tablets were used in each sample and two samples were taken. This, alongside the duplication of results, gives 8 tablets which were used in the determination using this method and an average taken. This increased the reliability of the results. During the procedures the same balances, burettes, flasks and pipettes were used so as to reduce the effects of error in these measurements. When titrations were carried out, a rough titration was initially done so as to determine the equivalence point. This was followed by accurate titrations. When two concurrent values were within 0.1cm3, an average was taken between these two values. The average was used to determine the mass of pure paracetamol greatly increasing the reliability of the results. Since the end point of the titration was not very obvious, previous titrations were kept aside so as to standardise the intensity of yellow in the solution, so that all titrations had the same end point colour. This increased the reliability of the titrations. All equipment used was cleaned using propanone to prevent chemicals from previous experiments contaminating this investigation. In addition to this the burettes and pipettes were rinsed with the solutions, before being filled with the same solution to prevent contamination. When using the balance, as far as possible, it was placed away from draughts and windows so as to prevent the wind causing error in the weighing of substances. Where possible, all reaction vessels and weighing receptacles were rinsed using a little of the liquid which would be used. This increased the yield of results, preventing the reactants being lost in the process. Modifications Initially, when dissolving the paracetamol in propanone, the tablet was not crushed however it took an inordinate time for the tablet to dissolve; by the time it had dissolved most of the propanone had evaporated The volume of propanone was increased from 20cm3 to 50cm3 because more paracetamol dissolved. This allowed a greater percentage of the paracetamol to be extracted from the tablets. Consequentially it took longer for the crude paracetamol crystals to form. Initially a sintered glass crucible was used to filter the recrystallised paracetamol. This resulted in the paracetamol being lost, so filter paper was fluted and used instead. This resulted in a greater mass of recrystallised paracetamol being collected. When the paracetamol was being added to sulphuric acid, initially it was unheated and just swirled, however not all the paracetamol dissolved and hence, the sulphuric acid was warmed with the paracetamol to dissolve the crushed tablet before being boiled under reflux. When using the ammonium cerium (IV) sulphate, it was found that if left for any length of time greater than one hour the solute came out of solution, therefore, before pouring the solution into the burette, it was stirred vigorously using a magnetic stirrer to ensure the same concentration of solution was used in every titration. Because of this, the burette was only set up immediately before use. Evaluation of results Both procedures resulted in significantly lower percentages than the mass of paracetamol in each tablet as stated on the box. The expected percentage by mass was expected to be 90.9%. This is calculated as shown: Mass of tablet – 0.55g Mass of paracetamol (on box) 0.50g (0.5/0.55) x 100 = 90.9% Generally the replicate compared well with the initial experiment, with a maximum difference of 4.6% by mass for the first procedure. For the second procedure there was a maximum difference of 5.2% by mass. This can be put down to errors in the equipment and human errors when carrying out procedures. The fact that both procedures indicated different formulations contained the most paracetamol, may be due to the fact that often paracetamol was taken from different blister packs, and hence from different batches, which may contain different masses of paracetamol. However human errors and errors in equipment are more likely to be to blame. It can also be broadly sai

Persuading on Genetically Modified Food Essay

The article called Genetically Modified Foods, has a style that is use to grab an audience emotion while still putting some facts. Right away in the first paragraph you will find ethos. Per Pinstrup-Anderson plays a key role in the article, he is the H.E. Babcock Professor of Food, Nutrition and Public Policy at Cornell University. Giving Per Pinstrup-Anderson a creditability, and having the audience attention. This is the only time in the article when ethos is being used to help their argument. In the next two paragraphs, Pathos and logos are used. It shows some facts as well as getting into the audience emotion. The way this was done was by talking about helping farmers in developing countries produce more food, making it more affordable to buy food, as well as not harming the environment. It goes on to say, â€Å"Many millions of people do not have access to sufficient calories and many more suffer from micronutrient deficiencies†. Another quote is, â€Å"which avoided mass starvation and helped millions out of poverty and hunger†. Notice they never gave an exact statistic on how many people are suffering from poverty and hunger, letting the audience see that it is so many people affected, and not just a specific number. It gives it more of a feel then would be given an exact number. In the next paragraph it goes back to logos, in the paragraph it is said science is the answer to fixing the hunger. It describes action that must be taken an order to be able to start helping starving people, as well as how will science help farming, like drought tolerance, mitigation of negative climate change, and pest resistance in crops. Those are just a few of what the paragraph claims to be able to do with a little investment for the technology. The way this paragraph is phrase is by letting the audiences see the processes that have to be done in order for an action to start. That way the audiences may start to have an opinion. At the end of this article it starts to talk about how long test must be done, and how the longer we wait the more expensive food will be as well as leaving millions to die. This passage is using pathos for its persuasiveness. It’s getting the audience that deep emotion of people waiting and starving. It goes on to say that anti-science ideology and the failure of the government brought the food crisis in the first place. This paragraph points a finger to show they are right, as well as preceding to say we have to change if something is not working. In the second article of, â€Å"The Failure of Gene-Altered Crops†, Vandana Shiva is presented as the ethos in this paragraph; she is the founder of Navdanya in India which is the movement of seed keepers and organic farmers. She written many books on how genetically modified foods are failing and how they will affect us. This grabs the audience attention because she’s a strong believer on organic substance. In the next paragraph it says we need biodiversity intensification that can work with nature instead of going against it, it doesn’t give a specific details as to why. The only argument made was when Doug Gurian-Sherman of the union of concerned scientist published a studied, â€Å"Failure to Yield†. In the study it is closely evaluated on the genetically modified for 20 years to see if they would increase yield or to just see better progress. In the end it showed that the experiment failed to increase yields as well as it failed to engineer crops to be insect-resistant nor herbicide tolerance. In this paragraph it was use ethos and logos. Ethos was Doug Gurian-Sherman and his research study, â€Å"Failure to Yield†. Logos was the bits of facts that came from Doug Gurian-Sherman research study. In the next to paragraph, it is shown by the International Assessment of Agricultural Science and Technology for Development [IAASTD] has concluded that genetic engineering did not seem very promising in the future. IAASTD found that the small farms that based on agri-ecology would produce much more food. This paragraph had also ethos, being IAASTD. As for the logos was what IAASTD found in the 4 years on figuring out what genetic engineering could hold in the future. The article makes a lot of tactics with logos and ethos to reach the audience, giving a great amount of facts from other credited people. The next three paragraphs have ethos as well as logos. In the passages, the book, â€Å"Soil, Not Oil† is brought as an example to give that industrial monocultures are more vulnerable to climate changes since the soil kept in organic plants help keep moisture making them less likely to die in draughts. In the next passage it is brought up the false statement by genetic engineering industry that it’s only possible to respond to climate change with modified food. Vandana Shiva made a statement on crops evolved to be better resilient to climate, as well Vandana has helped create seeds for drought resistance, and flood resistance as well as salt tolerance. This give the audience the idea that genetically modified food isn’t always needed when nature can just evolve. The last two passages gets more in depth on how genetically modified food and organically produced food will take us in the future. The passage give the audience a since of the future that genetic engineer for modified food is a waste a time, it does not give a sense of food security in the future and it will cause small farmers to go dept. As for Vandana Shiva Navdanya, it is a conserving biodiversity that tries to not be wasteful in water at the same time make much more food per acre. The best article that is persuasive is the second article, â€Å"The Failure of Gene-Altered Crops. The first article was very persuasive, but it never made it secure enough to make it believable that it close to happening. It produce more emotion then logic tactics, making it very hard to determine whether it is a dream that the nation wishes to reach or something that could be accomplish for the future. Great syntax on making it very emotional with pathos, but argument stance it would be weak. The first article could have been stronger if it talked about other countries that are already doing genetically modified foods. Korea has been doing genetically modified food for years, about 20 countries including the European Union, Japan, Australia and New Zealand have already a labeling system for genetically modified foods, (Hae-Yeong Kim 132). Another good point would be to bring up Matin Qaim, â€Å"Vitamin A deficiency is a serious nutritional problem, causing multiple adverse health outcomes. Simulations for India show that Golden Rice could reduce related health problems significantly, preventing up to 40,000 child deaths every year.(552) In India Bt cotton has reduce some poverty and actually help small famers, now some in China and South Africa, Bt cotton are a first-generation of genetically modified technology. As for the second argument, many ethos and logos were presented. One being Doug Gurian-Sherman published study on how genetic industries isn’t really going anywhere, it has great facts, it was a 4 year study so it showed what was being done in long term. A lot of facts on how genetic industry is failing on making modified food was claimed, but not many on how it could do more harm as well as it would bankrupt some small farmers for even trying to use modified seeds. The plant evolving had a great way point in Gebre Egziabher, Tewolde B( The Use of Genetically Modified Crops in Agriculture and Food Production, and Their Impacts on the Environment – A Developing World Perspective) â€Å"Scientists believe that species evolved from a common ancestor through competition and natural selection. They also believe that changes in genes occur in all species owing to mutation, with the probability of mutation of each gene remaining constant under the same environment†. (11) Giving this quote would remind the audience that life has a way of fixing itself and just because the technology is here does not give scientist right to use a different approach but instead try harder to help organic farming when it has been secure food source. Cite American Medical Assoc. Gebre Egziabher T. The Use of Genetically Modified Crops in Agriculture and Food Production, and Their Impacts on the Environment – A Developing World Perspective. Acta Agriculturae Scandinavica: Section B, Soil & Plant Science [serial online]. December 2, 2003;53:8-12. Available from: Science & Technology Collection, Ipswich, MA. Accessed April 27, 2012. American Medical Assoc. Hae-Yeong K, Jae-Hwan K, Mi-Hwa O. Regulation and detection methods for genetically modified foods in Korea. Pure & Applied Chemistry [serial online]. January 2010;82(1):129-137. Available from: Science & Technology Collection, Ipswich, MA. Accessed April 27, 2012. American Medical Assoc. Qaim M. Benefits of genetically modified crops for the poor: household income, nutrition, and health. New Biotechnology [serial online]. November 30, 2010;27(5):552-557. Available from: Science & Technology Collection, Ipswich, MA. Accessed April 27, 2012.

Bleaching Away the Beauty of Coral Reefs - 2340 Words

Bleaching Away the Beauty of Coral Reefs Pretend you are about to go scuba diving in the ocean. You jump in the water and begin to sink down. As you start surveying the coral reefs around you, something catches your eye. The coral has turned white, and no longer moves with life. This whiteness seems to have spread over a large area of the reef. You no longer see the colorful branches swaying in the current, or the schools of tropical fish swimming through the leaves. This death-ridden reef will never have the same life it once had. This phenomenon is known as coral reef bleaching. This makes corals unattractive and lifeless. The biodiversity of a reef is important to the ecosystem. There are different organizations that have†¦show more content†¦Lastly, the loss of coral will affect the successional stages of algae, which is important to the ecology of reef fishes. The loss will open up space, reduce the intensity of herbivory and, therefore, lead to colonization of the reef benthos by late-successional frondose algae. A dominance of frondose algae lowers benthic production and increases covers of the less palatable algae. The result is the reduced abundance of fish diversity (Rosenberg 165). These three effects all impact the biodiversity that thrives among reefs. It is very important to protect the reefs from dangers. In 1998, there were some experiments conducted to test these three ideas to see which one is the biggest factor is the problems with fish and fisheries. An increase in surgeonfish which supports the increased organic production idea. There was also a loss of damselfish, butterflyfish, and wrasse which supports the loss of fish hypothesis. The decrease in damselfish numbers in fished reefs exhibited both positively and negatively to increased algae. The bleaching phenomena can be used as a sentinel for the environment. It serves as an indicator of environmental stress. There still is no single cause for bleaching. D amage is already come and gone before bleaching is noticed. Observers must do retrospective analysis based on limited environmental data ( Rosenberg 402). Other effects of coral reef bleaching are its effect on tourism (Ray 214). ThereShow MoreRelated Bleaching Away the Beauty of Coral Reefs Essay2308 Words   |  10 Pagesstart surveying the coral reefs around you, something catches your eye. The coral has turned white, and no longer moves with life. This whiteness seems to have spread over a large area of the reef. You no longer see the colorful branches swaying in the current, or the schools of tropical fish swimming through the leaves. This death-ridden reef will never have the same life it once had. nbsp;nbsp;nbsp;nbsp;nbsp;This phenomenon is known as coral reef bleaching. This makes corals unattractive andRead MoreMyles Lawary. 4-4-17. Mrs.O’Connor. Marine Science..1216 Words   |  5 Pages Barrier Reef The Barrier Reef is the largest reef in the world, and it is located in Australia. It is made up of different types of coral and fish, but sadly the reef is bleaching. Bleaching is the process of water temperatures getting too warm and as a result coral reefs can bleach. When water gets too warm, corals will get rid of the algae living inside their tissues causing the coral to turn completely white. Although, when coral reefs turn white this does not meanRead MoreThe Greatest Significance Of The Great Barrier Reef1605 Words   |  7 PagesThe Great Barrier Reef is one of the seven wonders of the world. It extends more than 1,300 miles through the coral sea off northeastern Australia and it is even visible from outer space. It is also home to more than 400 types of coral and 1,500 species such as the tropical fish, birds, dolphins, and reptiles. 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Coral reefs, for example, may seem insignificant to the majority of people who don’t live near the coast of any continent, but provide so much to us that we need to focus more closely on how any change may impact them and, in turn, all of mankind. For over two million years the ocean’s coral reefs have been the root for many aquatic ecosystems (Hoegh-Guldberg, 1999). Many people may think of coral as rock formations and never fully realize that coral are living creatures. The coral reefsRead More The Coral Reefs Essay1559 Words   |  7 PagesThe Coral Reefs Can we save â€Å"Tropical Rain Forests of the Ocean†? Anyone who’s ever scuba dived at a coral reef and seen the perfect handprint of dead coral can appreciate how fragile and delicate this ecosystem is. Coral reefs are not just rock, like some people believe, but are an animal. Corals are a type of animal called a polyp, the simplest of predators that eat meat in the form of drifting zooplankton†¦all corals have boarders, zillions of microscopicRead MoreBird Species in Belize Essay1585 Words   |  7 Pagesin Belize. In a presentation by Angel Shavalier, she spoke about the coral climate changes. Discoveries have liked global temperature increase to radiation and fossil fuels. Impacted by these changes are increasing pH and carbon levels, creating dangerous environment changes. When the ocean acidifies, any shelled animal are extremely sensitive to it and it alters their life cycles. Belize holds the second largest coral reefs, and about half have been bleached due to abnormally high temperaturesRead MoreMy Country the Maldives1803 Words   |  8 Pagesa series of disasters in the past few years including the coral bleaching wrought by el Nià ±o and the horror of the 2004 tsunami. Indeed, so superior are its beaches, so cobalt blue its waters and so warm its welcome that the country has become a byword for paradise whether it be for honeymooners, sun worshippers or divers. A geological eccentricity nestled in the middle of the Indian Ocean, the Maldives are a series of ancient coral reefs that grew up around the sides of towering prehistoric volcanoesRead MoreOil Drilling And Its Effects On The Environment Essay2241 Words   |  9 Pagesit is incredible. There is so much diversity and beauty some of which has not yet been discovered. Coral reefs happen to be one of the most diverse ecosystems on earth where many species know them as home. Along with their incredible beauty and diversity, coral reefs happen to be at risk of extinction, â€Å"†¦coral reefs, the so-called rainforests of the sea, which are the most diverse marine ecosystems and among the most threatened† (0215). Coral reefs are at risk and they are only one of the few ecosystemsRead More Shipping and the Great Barrier Reef Essay4636 Words   |  19 PagesShipping and the Great Barrier Reef Australia’s Great Barrier Reef (GBR) is an unparalleled marine ecosystem that holds rank as one of the world’s most valuable natural wonders. The abundance of sea life offers both intrinsic and physical benefits, but unfortunately this extraordinary habitat is now threatened from several different angles. One of the greatest threats to the GBR is the presence of popular shipping routes which surround and penetrate the reef. These ships naturally pollute

Aids, Expertise, And The Rise Of American Global Health...

Scrambling for Africa: AIDS, Expertise, and the Rise of American Global Health Science HIV is the virus that causes Acquired Immunodeficiency Syndrome, commonly known as AIDS. HIV/AIDS has become one of the most destructive global pandemics in history. In 1990, the World Health Organization estimated that over one million people were living with AIDS, and in less than ten years, HIV had exploded worldwide (Perlin Cohen). Johanna Tayloe Crane, a medical anthropologist, dedicated her career to studying the way political and economic inequalities influence how HIV/AIDS is researched and treated for in Africa. Crane complied over ten years of ethnographic research to study a HIV research partnership between a US university and Ugandan universities and clinics. Her book, Scrambling for Africa: AIDS, Expertise, and the Rise of American Global Health Science, unpacks both the American and Ugandan researcher’s and clinicians’ perspectives about the research partnership and cri tiques the U.S. response to the AIDS epidemic in Africa. Her findings reveal the paradox of health institutions and their global health research partnerships benefit from the inequalities they are trying to readdress. These global, economic, and scientific inequalities have allowed Global Health Science research partnerships to establish their own authority over Africa’s HIV/AIDS epidemic. 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Movie Review Taken - 1143 Words

The movie I chose to analyze for my assignment is ‘Taken’. The movie is a 2008 English-language French action thriller film directed by Pierre Morel, and written by Luc Besson and Robert Kamen. The music is composed by Nathaniel Mechaly. Bryan Mills, who is a former U.S. Central Intelligence Agency operative, tries to have a closer relationship with his daughter, Kim, who lives with her mother and stepfather. Later on Kim asks Bryan for permission to travel to Paris with her friend Amanda. Bryan doesn t want the two girls traveling alone, but finally agrees to let them. Bryan then gives Kim and international cellphone before going to the airport. Once they arrive at the airport, Bryan finds out that Kim lied to him about going to Paris, and instead Kim and her friend are going to follow a band during their European tour. Once Kim and Amanda arrive in Paris, they meet a guy who is a scout for a kidnapping gang. The guy follows them to the place where they are staying. Wh en Kim is talking to Bryan on the phone in the bathroom, Kim sees Amanda being kidnapped by a group of guys. Bryan tells Kim to go to the nearest room and hide under a bed. He tells Kim when the men find her, to shout out what they look like. Once the intruders find her, she yells out their physical appearance before her phone is found. Bryan then tells the guy that the group has just this one time to release his daughter, and if they don’t, he is going to travel to Europe and find them and kill them.Show MoreRelatedEssay on Review and Analysis of the Movie Taken785 Words   |  4 Pagesto describe the movie Taken. If you desire a high dose of adrenaline to quench your movie watching thirst, and if you are ready to take a super-charged ride to the action filled city of Paris, France, then this is a must see movie for you. Taken, not for the faint of heart, will keep you on the edge of your seat for the entire ninety-one minutes. 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A Day in the Life of David M. Foster Free Essays

string(61) " About 30 minutes later, dinner is ready and out pops Ellie\." A day in the life of David M. Foster begins early. The alarm clocks begin sounding at 0445 Monday morning, even though I don’t get up until almost 0530. We will write a custom essay sample on A Day in the Life of David M. Foster or any similar topic only for you Order Now I am a deep sleeper and have a hard time waking up. My wife, Sarah, is not a heavy sleeper and is constantly awoken by my myriad of alarm sounds while I attempt to wake up enough to get out of bed. At 0530, I get up, turning off all the alarms so as not to aggravate my wife further. In a face-saving gesture, Sarah says nothing and acts as though she were asleep the entire time. Face-saving behaviors are â€Å"techniques used to salvage a performance (interaction) that is going sour† (Henslin, 2011, p. 114). Sarah has acted this way so that I don’t feel badly about waking her, even though we both know that my inability to get up quickly irks her each and every morning. I have to catch the bus, so I rapidly get dressed and grab my bag. When I get to the bus stop, there are several people there, but because the temperature is so low (about 20 degrees), no one says much. We generally keep to ourselves that early in the morning anyway. I do nod to those who are senior to me in rank and position in the military, as is customary for the services. One is expected to give the â€Å"greeting of the day†, basically a â€Å"good morning† to those who are senior in rank to you. Because I am of a junior rank, even as a seasoned NCO, I play that role. I have been playing that role for more than 15 years at this point and have come to acknowledge that it is part of my self-concept (Henslin, 2011, p114). At 0550, the bus arrives, late as usual. Just as soon as I sit down on the bus, I shoot off a text message to my supervisor, SFC Cooper, letting her know that I’m on the bus. The reason for this is two-fold. One, accountability formation is at 0630 (the bus ride is 20 minutes, minimum) and two, to let her know that I’m on the bus and didn’t just oversleep. The US Military ingrains certain standards of action into you as resocialization. Resocialization is â€Å"the process of learning new norms, values, attitudes, and behaviors† (Henslin, 2011, p86). These standards become norms. Norms are â€Å"expectations or rules of behavior that reflect and enforce behavior† (Henslin, 2011, p46). One of hese norms is that you must arrive 10 minutes prior to any formation. This is not a more, but a folkway. Not arriving at the appointed time violates a more. A folkway is a â€Å"norm that is not strictly enforced† (Henslin, 2011, p49), while a more is a â€Å"norm that is strictly enforced because it is thought essential to core values or to the well-being of the group† (Henslin, 2011, p49). At 0615, we arrived at the gate to Patch Barracks, the military Kaserne, or installation. The civilian guard is a Local National, so I greet him with a â€Å"Guten Morgen† (German for Good Morning). If he had been one of the few American guards, I would have just spoken in English. At 0635, after our accountability formation, I change into my uniform for the day, the Army Combat Uniform. The Uniform helps to indentify the subculture that we all belong to. Each service has its’ own uniform and its’ own subculture. A subculture results from â€Å"the values and related behaviors of a group that distinguish its members from the larger culture† (Henslin, 2011, p49). The US Military is a subculture of the United States of America and the US Army is a subculture of the US Military. Fast forward to after breakfast, its 0800 and I arrive (ten minutes early) for the Equal Opportunity Leader (EOL) Course that I am attending this week. Here I meet SFC Trussell, the instructor for the course and also the Equal Opportunity Advisor (EOA) for the Stuttgart, Germany area. SFC Trussell is my senior, so I defer to him and address him as â€Å"Sergeant†, which is in line with our folkways and mores. During the first part of the training today the students are all required to create a â€Å"badge†. This is done using a graphic and 5 words to describe your characteristics, list your demographic information, and group affiliations. The point of this exercise is as an â€Å"Ice-breaker† but also to help others understand how you relate to the world around you. The rest of the day is dry and boring. Having 15 years of experience, most of the course material in the EOL course is not new to me. Sarah has driven down to Patch Barracks and dropped off the car, so I don’t have to catch the bus home tonight. At 1715, I swing by the office and check in with SFC Cooper and answer a few emails to my counterpart at our higher headquarters. Nothing new, mostly routine stuff. At 1740, it’s into the car and off for the 40 minute drive home. Traffic is much worse in the evening than in the morning. I get home at 1820, walk through the front door, and immediately drop everything because here comes Molly. Molly is 4 years old and runs for me as soon as I open the door, yelling â€Å"Daddy’s home†! I grab her off the floor and give her hugs and kisses, transitioning from my role as â€Å"Soldier† to my roles of â€Å"Father† and â€Å"Husband†. This goes on with Molly for about 5 minutes before she begins to lose interest (as 4 year olds generally do) and I put her down, giving Sarah a kiss and asking how her day was. Our interaction is not very detailed as we both need time to decompress from our recent role changes. Sarah has gone from mother mode to wife mode as I have just entered the father role and can assist in taking care of the children. About 30 minutes later, dinner is ready and out pops Ellie. You read "A Day in the Life of David M. Foster" in category "Life" Ellie is 13 and regardless of the questions asked, her responses are seldom more than a word or two, â€Å"typical† behavior for a teenager. At 1920, dinner is over and it’s washing up time. At this point, everyone drifts off to do whatever we normally do, sticking with our own routines. I log into my online game, Eve Online, and chat with my friends there. Molly goes back to her â€Å"before bed† cartoons, Ellie disappears back into her room to do whatever teenagers do in their rooms, and Sarah logs onto her computer to chat with friends on Facebook and read the English newspapers online. I play Eve Online until 2200, the appointed time for my group to play, chatting about work, news, and such while engaging in space combat. At this point it’s time for me to pack my bag again for the next day, preparing to start all over. At 2245, it’s into bed and lights out. Day done! As I typed my Journal, I realized that the majority of my day is consumed by playing the role of Soldier. The structure of the US Military is such that almost every facet of your daily life, from the time you wake up, to the clothes you where, to the way you address people, is determined prior to the situation. Out of a 17 hour day, more than 12 hours of it is consumed by the â€Å"Soldier† role. Because I have been in the US Military for 15 years, I am fully indoctrinated and invested in this system, whether I realize it or not. I also realized that there is a specific moment when I transition from the Soldier role. Specifically, this is the moment I walk through the door and am â€Å"attacked† by my youngest daughter. If not for her, I might get â€Å"stuck† in the Soldier role, unable to do anything else. The importance of keeping this â€Å"Soldier† role at the forefront every day is simple: it provides the livelihood for me and my family. Without the US Military, and my participation in it, I would be forced to find alternate means to care for my family. I posses skills to do so now, but only because the US Military taught them to me. I was socialized in adulthood in the US Military. A day in my life is likely similar to most. The discerning factor is probably the US Military ties, though many of my classmates are also members of a military subculture. The subculture of the US Military dominates my daily life by design. The US Military requires individuals to be prepared to do extraordinary things and so requires a higher level of commitment (and indoctrination) than a job at McDonald’s might. The role of Soldier is a vast part of â€Å"who I am†, but I am also â€Å"Father† and â€Å"Husband†, as well as â€Å"friend†, â€Å"coworker†, â€Å"peer†, and â€Å"superior† to many, many people. I wouldn’t change a thing†¦. well, maybe the 0445 alarm clock. Journal All times in 24 hour clock. 8 February 2013 0445Alarm Sounds 0530Get out of Bed without waking wife any more than alarm has already. 0530-0545Dress in US Army Improved Physical Fitness Uniform (IPFU) 0545Grab bag, packed night before, and head to bus-stop. Temperature well below freezing with snow on the ground. Nod to others at bus-stop, no one really speaks, too cold. Several of the people at the bus-stop are higher ranking (which is normal). 0550Bus arrives, late as usual. Sent text message to SFC Cooper (Supervisor and Platoon Sergeant) saying â€Å"On the Bus†. 0550-0620Bus ride to Patch Barracks. Pulled hat down and slept (which is also normal). 615Showed ID Card to Gate Guard, said â€Å"Good Morning† in German since the guard is a German national. 0620Depart bus at second stop and walk to gym for first formation. 0625Drop bag in locker room, head to formation. Make sure supervisor/Platoon Sergeant see that I am present. Get brief for day from Detachment Sergeant (Upcoming events, etc. ). Fall out of formation because I am not doing Physical Training, reminded Platoon Sergeant/Detachment Sergeant that I had EO Course this week. 0635Back into Locker room to change into Army Combat Uniform (ACU’s). 0635-0715Shower, Shave, change, etc. 0715Depart Gym to Kantine for breakfast. 735Arrive Kantine, order eggs, sausage, Brotchen, coffee in German because the cook is a German national that has been working there for a significant period of time. 0740Pay for Breakfast in Euro instead of US Dollars 0750Drop tray and head to Equal Opportunity Leader (EOL) Course across the parking lot. 0800Met SFC Trussell, the instructor and also the Stuttgart Garrison Equal Opportunity Advisor (EOA). 0830During first block of training must complete the â€Å"Badge† exercise. Required to use 5 words and a picture to describe characteristics, demographic data, and group affiliation (annotated below). Stood up in front of class of 24 other Non-Commissioned Officers (NCO’s) and explained my â€Å"Badge†. I know several of them, some from my Unit and some from other units in the area. Schedule for the class is tight, trying to finish 6 days of training in 5. Keep most of my comments to myself so as not to drag out the class with empty discussion. 0900-1130Some interaction with classmates, though not much. It’s day one of the course and we are just getting to know one another, as well as keep up with the fast pace of the rather dry subject matter. Couple of â€Å"smoke breaks† thrown in, but not on any schedule (I’m a pack a day habit). 1048Sent â€Å"I Love You† text to wife. Got same in response. 1130Break for lunch. Walk to food-court. Lunch at Burger King. Remark to clerk about high prices and how they are similar to US Prices. Had a chicken sandwich, fries, and sweet tea. 1245Head back to class. 1300-1700Instruction resumes, not much deviation from the morning block. 1630Got a text from the wife, car has been left at work for me to take home so I don’t have to ride the bus. Reply with â€Å"Thanks Babe† 1700Class ends, pack up and leave classroom. Speak with SFC Williams (from my unit) briefly about the class and whether or not to go back to office before heading home. 1715Enter office to check email and find SFC Cooper still there (Workday ends at 1700). She asks me about class and I explain that it’s fast paced but dry. I have been in the Army 15 years, I know all of the course material from previous training. Checked email and responded to several requests for information from my counterpart (SFC Stewart) at the level above me (BDE). 1740Log-off computer and go to car. 1745-1820Traffic and drive home. 825Enter home, Molly (4) runs to me yelling â€Å"Daddy, Daddy! †. Pick her up and give her a big hug and kiss. She immediately begins telling me about her day, though most of her responses are â€Å"I don’t remember† to questions I ask. 1830Put Molly down and kiss wife, ask her how her day was. Response is â€Å"not bad†. She asks how my day was and I respond with â€Å"long and boring. Class is dry. † 1830-1845Change into regular clothes. 1845Check personal email, nothing important, mostly spam. 1850Sit down to dinner, eating English Shepard’s Pie. Molly complains and Ellie (13) comes out of her room long enough to eat. Try to start conversation and basically get one word answers. Typical Teenager responses. 1920Dinner finished, clear table and rinse dishes. Back onto computer to play. 1930Log in to Eve Online (MMORPG) and greet my â€Å"friends†. 4 people who live in the same town are my â€Å"corps mates†. 1930-2200Rambling conversation about work and Eve, all during co-op play using very expensive (in-game) items to earn massive amounts of in-game currency. 2200â€Å"eve time† ends, log off. 2215-2240Pack bag for tomorrow, say good night to wife (who stays up later than me). 2245Lights out and to sleep. How to cite A Day in the Life of David M. Foster, Essays

Strategic Alignment Influence Organization †MyAssignmenthelp.com

Question: Discuss about the Strategic Alignment Influence Organization. Answer: Introduction The Information System has been increasing its potential in the business organisation. The Information System is implemented with the strategic business convocation in the market. This literature review deals with the strategic events of the Woolworth Supermarkets, Australia. The organisation stricture and its overview has been discussed in the report. The recent market analysis and operational management of the company has been analysed properly in the report. This report outlines the accounting software used by the company and its demerits. The leaders of the market has been properly discussed in the report for analysing the competition in the market. The challenges and gaps in the accounting software are resolved with the help of different strategies. Woolworths Supermarket is one of the largest retail market chain in the Australia founded in 1924. It has grown up to a huge retail market chain all over the world. There are more than 1000 stores in Australia and 968 supermarkets. It has received its revenue from food and groceries stores. Woolworth group had a turnover of $27.9 billion in FY2004 in which food and liquor contributed $22 billion (Woolworths.com.au, 2017). Both the above figures are showing the organisational structure of the Woolworths Supermarket. The companies gave the managing director at the top of the hierarchy. Organisational Problems There is a drastic change in the revenue of the company over the years. These changes have raised due to the fluctuations in the market share of the company in the market. The operational strategies of the company have gone wrong for the company in the market. The change on the operational system of the company have not shown any huge growth in the market (Galliers and Leidner 2014). The increase in the number of the competitors in the market has causes threat for the company. The company is not able to fulfil the requirements of the customer in the market. There a huge change in the market share of the company in the recent years. The degradation in the demand and price of some gods have caused loss for the company. The price of some other goods have increased in the store of the company that has lost sight of the customers in the market. The company has shown inefficiency in fulfilling the requirement and expectation of the customers in the market. This system has caused loss in the market for the company. The customers are getting distracted due to the increase in the price of the product sin the stores of the company. The structure of the organisation has not able to perform in the operational management of the company. The company has not fulfilled the vision and mission statement of the company. The marketing terns and department of the company not worked properly that have neglected the image of the company in the market (Peppard and Ward 2016). The marketing of the products and services of company in the market has not been done properly that has caused depletion in the resources of the company in the market. The system acquisition method of the Woolworths Supermarket is based on the ERP model. The above figure describes about the new model of the company that is designed by the CEO of the company. The SAP model has been implemented in the company for providing stability to the company in the market (Pearlson, Saunders and Galletta 2016). The new ERP model of the organisation has able to channelize the relationship with customers in the market. The ERP system has able to focus on the retail stores of the company and providing products at a low price to the customers. The SAP has helped in maintaining the database of the company in the market. A properly arranged database helps in proper fetching of the data and information regarding the operations performed in the organisation. System Flowchart of sales procedures The above figure is a System Flowchart of sales procedure of sales process of the company. This procedure helps in maintaining the visual effect of the sales process and identifies related issues and challenges in the sales process of the company (Coviello and Tanev 2017). The flow chart has described about the sales procedure of the Woolworth Supermarket, Australia. The flowchart provided above signifies that the customer has to submit the post order (PO) on the online website. The process has to be executed and is processed by the portal. The agent of the company have reviewed the order provided by the customer (Cassidy 2016). The agent provides conditions of the products, the standard terms, and approves the order. The order is under terms and conditions, the request of the agent is proceed for the approval of order from respective customer. The payment process might be initiated for the customers after the confirmation of the order. The customer have to make the payment with the help of the payment gateway. There are some changes in the product asked by the company and the customer makes changes according to their choice. If there is no changes in the choices and order of the customer, the order is ready for the delivery (Nguyen, Nguyen and Bosch 2017). The order is shipped for delivery and send to the local dealer of the order nearby on successful transaction. After that, the delivery individual successfully delivers the order to the customer. The principles of the operational body of the company revolves around the shareholders and customers (Wu et al. 2015). The retail market of the company is affected by external factors including the environmental and social influences of the company. The problems that are affecting the brand image of the company in the market. These problems includes the bad products and services of the company in the market. The tangible products and services are constituted with the retail sector in the market. These services requires the participation of the customers for maintaining the engagement of the employee in the company (Li, Cui and Lu 2017). The services offered by the company have been continuously degrading uts quality that has cause decrement in the sales of the company. The company has not changed the structure of the organisation according to the change in the market trends (Ismail and King 2014). The interaction with the customers has changed that has caused loss to the company. The self-checkout facility is not present in the stores and outlets of the company that has caused many problems or the customers at the stores. The staffs and employees of the company are not behaving properly with the customers at the billing counter. The managers at the outlets of the stores are responsible for the development of the outlets in the local area. Forecasting deals with forecasting the future strategies for developing the outlets and stores of the company in the market. The store manager is also responsible for developing methodology of researching the outlets of the company (Kavanagh and Johnson 2017). The manager of the store is relayed in the qualitative approach of the historical data and statistics. The manager is unaware of the current changes in the market causing no change in the product specification and price in the outlet. The supply chain deals with the process of providing materials from the dealer to the wholesalers. The main part of the chain is the customers of the company. The management if the supply chain is important to maintain for engaging the customers with the company. This is the integration of the activities for procuring the materials and services for transforming into immediate products. There are various frauds prevailing in the organisational system of the company. The delivery of the wrong product to the customer is one of the major problems of the companies. Various outlets ask for extra charges for the delivery and other stuffs. This is an illegal activity offence by the outlets of the company. The customers does not get same product as ordered in some cases. Accounting software packages The challenges in the Woolworth has helped in focusing on the gaps and loopholes of the company in the market (Appelbaum et al. 2017). The company have to focus on the challenges faced in the market. The company has followed the B2B connections that provides a proper connection with the other brands provided in the company. The B2B solutions helps in facilitating the third party technology providers for helping in solving the technical complexity of company in market. The B2B solution provides technical messaging solutions to exchange a wide range of information flows in the organisation. The market size of the Woolworth Supermarket is always at the top of the market. The company has able to fulfil the needs of the customer in the market. The market of the company has been rising continuously in the market with increasing number of customers. In the recent years, the market share of the company has shown decrement. In September 2016, there is a loss of $825 million in the market for the company (Sun et al. 2017). The current market trend of the company has shown drastic changes in the market. Coles has provided a tough competition to the Woolworth Supermarkets. The Coles has able to capture a huge amount of customer in the market. The competitive strategies of the company is different from the Woolworth in the market. The Coles have provided new trends in the market that has helped in attracting the customers to them. The Woolworth has invested around 41 billion in lowering the prices of the products in the market to provide a competitive advantage to the Coles. Limitation and Recommendation There are various limitation sin the operational strategies of the company in the market. The Woolworth is using the B2C strategy for gaining the competitive advantage (Hallikainen et al. 2017). The company is unable to fulfil the requirements of the consumers in the market that can be a bug trouble for the company in the market. Therefore, it is recommended to use the B2B software package for allowing any type of technical data of company. The company have to start new outlets for implementing B2B solution package in market. The company have to approach towards the client directly to implement the B2B solution sin the operation management. Conclusion It is concluded that the Woolworth Supermarket has been able to maintain the top position in the market. The operational strategies of the company have been exercising the interest of the customer in the market. The structure of the organisation have been able to maintain a proper hierarchy. This has helped in resolving the queries of the employees and other staffs. The B2B accounting software packages has helped in performing a proper agenda to the company in order to make success I the market. References Abraham, T. and Dao, V., 2017. An Empirical Investigation of Sustainability Innovation Systems and the Stages of Sustainability Maturity. Appelbaum, D., Kogan, A., Vasarhelyi, M. and Yan, Z., 2017. Impact of business analytics and enterprise systems on managerial accounting.International Journal of Accounting Information Systems,25, pp.29-44. Cassidy, A., 2016.A practical guide to information systems strategic planning. CRC press. Coviello, N. and Tanev, S., 2017. Initiating a New Research Phase in the Field of International Entrepreneurship: An Interview with Professor Nicole Coviello.Technology Innovation Management Review,7(5). Galliers, R.D. and Leidner, D.E. eds., 2014.Strategic information management: challenges and strategies in managing information systems. 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Li, M.H., Cui, L. and Lu, J., 2017. Marketized state ownership and foreign expansion of emerging market multinationals: Leveraging institutional competitive advantages.Asia Pacific Journal of Management,34(1), pp.19-46. Madhavaram, S. and Hunt, S.D., 2017. Customizing business-to-business (B2B) professional services: The role of intellectual capital and internal social capital.Journal of Business Research,74, pp.38-46. McKnight, D.H., Lankton, N.K., Nicolaou, A. and Price, J., 2017. Distinguishing the effects of B2B information quality, system quality, and service outcome quality on trust and distrust.The Journal of Strategic Information Systems,26(2), pp.118-141. Nguyen, T.V., Nguyen, N.C. and Bosch, O.J., 2017. Enhancing the competitive advantages of Vietnamese coffee through the exploration of causal loop modelling in the supply chain.International Journal of Logistics Systems and Management,26(1), pp.17-33. Pearlson, K.E., Saunders, C.S. and Galletta, D.F., 2016.Managing and Using Information Systems, Binder Ready Version: A Strategic Approach. John Wiley Sons. Peppard, J. and Ward, J., 2016.The strategic management of information systems: Building a digital strategy. John Wiley Sons. Sun, Z., Strang, K. and Firmin, S., 2017. Business Analytics-Based Enterprise Information Systems.Journal of Computer Information Systems,57(2), pp.169-178. Woolworths.com.au. (2017). {{metaController.metaData.title}}. [online] Available at: https://www.woolworths.com.au/ [Accessed 11 Aug. 2017]. Wu, S.P.J., Straub, D.W. and Liang, T.P., 2015. How information technology governance mechanisms and strategic alignment influence organizational performance: Insights from a matched survey of business and it managers.Mis Quarterly,39(2), pp.497-518.